Endocrine Abstracts

Mild autonomous cortisol secretion (MACS) has been associated with cardiometabolic risk factors and cardiovascular disease in the 2000s and with increased mortality in the 2010s. Since the range of cortisol after dexamethasone suppression (cortisolDST) in MACS is wide, the associated risk may vary. To adequately decide treatment, the risk associated to the different levels of cortisolDST must be known. This year the ENSAT group published a study on cardio...

Introduction: The specificity of cortisol after 1 mg dexamethasone (cortisolDST) ≥50 nmol/l as a criterion for mild autonomous cortisol secretion (MACS) is approximately 80% in patients with adrenal incidentalomas (AI). The aim was to study the associations of cortisolDSTto age, BMI, and renal function. We used machine learning models to uncover potential non-linear associations.Methods: We studied 1129 patients with AI examin...

Background: Low levels of DHEAS, such as <1.04 µmol/l, have been used as a criterion for autonomous cortisol secretion (ACS) in patients with adrenal incidentalomas. Age- and gender-specific cut-off levels could theoretically improve DHEAS as a marker of HPA-axis suppression and as a criterion for ACS.Objective: We aimed to find cut-off levels of DHEAS that are best associated with HPA-axis suppression and determine whether they are correlated w...

Osteoporosis and the associated low- energy fractures is a major public health problem. Phytoestrogens, especially from soy foods with isoflavones, carry the potential of being a nutritional candidate for prevention of osteoporosis. Several studies have been performed to determine the role of soy intake in preventing bone loss in postmenopausal women. Studies with fracture endpoint are not yet available, but several other lines of evidence have been investigated: epidemiologic...

Introduction: Phaeochromocytomas often induce hyperglycaemia. Few cases are reported with hypoglycaemic fits. The mechanism is unknown. Our findings may indicate a mechanism.The patient: A 37 year old female had a phaeochromocytoma, with typical characteristics: attacks of headache, nausea and sweating. High blood pressures, up to 237/134. Electrocardiogram indicated ischemia, normal coronary arteries on dynamic CT, normal Echo-Doppler heart examination....

Background: Autonomous cortisol secretion (ACS) in patients with adrenal incidentalomas (AI) has been associated with increased mortality in previous small studies. Our aim was to evaluate if ACS is a risk factor for mortality in a large population of patients with AI.Methods: Consecutive patients examined for adrenal adenomas, found as AI, without catecholamine or aldosterone hypersecretion between 2005 and 2015 were included and followed for up to 14 y...

Aims/hypothesis: Circulating erythropoietin (EPO) and vascular endothelial growth factor (VEGF) increase during hypoglycaemia and may represent a protective hormonal counter-regulatory response. We tested the hypothesis that low levels of EPO and VEGF are associated with a higher frequency of severe hypoglycaemia in a cohort of patients with type 1 diabetes.Methods: Two hundred and nineteen patients with type 1 diabetes (41% females, age 46±13 years...

Disparities in the quality of care for patients with type 1 diabetes (T1D) undergoing transition from children’s to adult services are well recognised. Poor planning and ill-defined care pathways promote patient disengagement with many becoming ‘lost’ to specialist follow-up for years. This study sought to obtain the views of young people’s experiences of transition to identify perceived barriers to an effective and rewarding transition experience. A qualit...

Introduction: There are limited data on the effectiveness and safety of GHRT in older patients with AGHD. We compared real-world GHRT outcomes in older (aged ≥60 years) vs middle-aged (35–<60 years) adults.Methods: NordiNet® IOS (NCT00960128) and ANSWER (NCT01009905) were non-interventional studies investigating long-term effectiveness and safety of GHRT with Norditropin® (somatropin, Novo Nordisk). Safety was assessed in the ful...

Background: Subclinical hypothyroidism is associated with a number of cardiovascular risk factors such as hypertension, hypercholesterolemia, and diastolic dysfunction, but only limited data exist on long-term outcome of levothyroxine substitution therapy.Objectives: To examine effects of levothyroxine substitution treatment on mortality in patients with subclinical hypothyroidism.Study design: Historical cohort study.<p class=...